Trazodone and Weed: Interactions and Risks

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Introduction

Depression is a pervasive mental health condition that affects millions of people in the United States. It comes in various forms and degrees, impacting individuals differently. While there are several treatment options available, including medications like SSRIs and therapies, some people turn to unconventional approaches, such as medical marijuana. One question that arises is whether it's safe to combine Trazodone, a commonly prescribed medication for depression, with cannabis. 

In this blog post, we explore the interactions and risks associated with using Trazodone and weed together.

What is Trazodone?

Trazodone is an antidepressant medication used to treat depression, anxiety, or a combination of both. Administered orally, it comes in different dosages tailored to individual needs. Trazodone primarily acts on the body's serotonin levels, aiming to restore them to a healthy balance. While it's considered effective, especially for depression, it can also be prescribed for conditions like PTSD, sleep disorders, and bulimia. It's important to note that its only FDA-approved application is for depression. Some common side effects include constipation, dry mouth, headaches, tiredness, and nausea. Brand names for Trazodone include Desyrel, Desyrel Dividose, and Oleptro.

Trazodone and Medical Marijuana: How Do They Interact?

Combining Trazodone and medical marijuana is a topic with limited scientific research, but some insights are available. When used together, they might increase heart rate and enhance the drowsiness associated with cannabis, particularly in individuals new to this combination. It's interesting to note that one study suggested Trazodone as a potential treatment for cannabis use disorder. 

However, if you are contemplating using both substances, consulting your doctor is essential. They can provide more information and help you make an informed decision, ensuring you're aware of potential risks.

Related: Combining Cannabis and Cold Medicine: Is It Safe?

Are There Any Benefits to Taking Trazodone and Cannabis?

While research on the combination is scarce, there is some preliminary evidence about cannabis potentially improving certain symptoms of depression. However, it's crucial to be aware that cannabis could exacerbate other depression symptoms, such as drowsiness and changes in eating habits. Consulting your physician before mixing medical marijuana and Trazodone is advised to ensure safety and informed decision-making regarding your mental health treatment.

What are the Risks of Combining Trazodone and Weed?

As with any medication combination, it's vital to understand the potential risks of combining Trazodone and cannabis. This combination may lead to breathing and central nervous system depression. Although these effects are unlikely to be life-threatening, it's important to be cautious. Possible side effects enhanced by this combination include sedation, respiratory depression, reduced psychomotor skills, judgment impairment, and thinking impairment. 

Additionally, there is a risk of serotonin syndrome, which occurs when certain medications elevate serotonin levels excessively. Although cannabis alone is unlikely to cause serotonin syndrome, the combination of cannabis and Trazodone could potentially trigger it. If you're concerned about this syndrome, discussing your options with a healthcare professional is crucial.

Related: Five Common Illnesses Patients Use Medical Marijuana For

Safety Tips When Using Trazodone and Cannabis

If you're contemplating using Trazodone and cannabis together, it's advisable to have a conversation with your healthcare provider to ensure the best approach for your mental health. There might be alternative options available that offer the same benefits while minimizing side effects and health risks. 

Keep in mind that the duration Trazodone stays in your system can vary depending on factors like dosage, individual metabolism, and the duration of use. If you've just started taking Trazodone, it might exit your system in a matter of days, while long-term use could result in a more extended presence. Your individual situation should guide how long you should wait after using Trazodone before consuming cannabis. 

Lastly, if you experience adverse effects after using this combination, seek medical attention promptly. Your well-being is paramount, especially when combining different substances.

Headshot of Steven Fiore, MD

This article has been reviewed by Steven Fiore, MD.

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