CBD vs. CBG: What Are The Differences?

CBD vs. CBG: What Are The Differences?

The cannabis industry has experienced a surge in popularity, and as wellness trends evolve, people are exploring various compounds derived from the Cannabis Sativa plant. Among these, two cannabinoids have gained significant attention: Cannabidiol (CBD) and Cannabigerol (CBG). 

While CBD is widely recognized for its therapeutic benefits and is commonly used in wellness products, CBG is still relatively unknown to many. 

In this article, we’ll compare these two fascinating cannabinoids, exploring their similarities, differences, legal status, potential benefits, and limitations.

What is CBD?

Cannabidiol (CBD) is one of the most well-known and extensively researched cannabinoids. Derived from the Cannabis Sativa plant, CBD is a non-psychoactive compound, meaning it doesn't produce the "high" typically associated with cannabis use. Unlike tetrahydrocannabinol (THC), which is the primary psychoactive component, CBD interacts with the body’s endocannabinoid system (ECS) in a way that can help regulate pain, mood, and stress, among other bodily functions.

Related: CBD vs. THC: How Do They Differ?

Potential Benefits of CBD

  1. Pain Management: CBD has been studied for its potential to alleviate chronic pain, particularly in conditions like arthritis, multiple sclerosis, and fibromyalgia. Studies suggest that CBD can reduce inflammation, which may contribute to its pain-relieving properties.

  2. Anxiety and Stress Relief: Many people use CBD for its calming effects, which may help reduce anxiety, stress, and symptoms of post-traumatic stress disorder (PTSD). Early research supports its potential to manage anxiety without the sedative effects of traditional medications.

  3. Epilepsy and Seizure Disorders: One of the most well-documented uses of CBD is in the treatment of epilepsy. Epidiolex, a CBD-based medication, has been approved by the FDA for treating certain types of epilepsy, especially in children.

  4. Sleep Aid: CBD’s potential to promote relaxation has made it a popular choice for improving sleep quality. It may help those who struggle with insomnia or sleep disturbances due to anxiety or pain.

CBD vs CBG

Popular CBD Products

CBD is available in various forms, including oils, tinctures, capsules, edibles, topicals, and vapes. The versatility of CBD products makes it easy for users to incorporate it into their daily wellness routines, catering to different preferences and needs.

What is CBG?

Cannabigerol (CBG) is another non-psychoactive cannabinoid, but it is less well-known compared to CBD. CBG is often called the "mother cannabinoid" or "stem cell" cannabinoid because it serves as the precursor to other cannabinoids like CBD and THC. While CBG is found in lower concentrations in most cannabis strains, its potential therapeutic effects have sparked interest in the scientific and wellness communities.

Potential Benefits of CBG

  1. Anti-Inflammatory Properties: Like CBD, CBG has shown promise in reducing inflammation. Research suggests that CBG may have particular benefits for conditions like inflammatory bowel disease (IBD), Crohn's disease, and colitis.

  2. Glaucoma Treatment: CBG has been studied for its potential to reduce intraocular pressure in the eyes, making it a possible treatment for glaucoma, a condition that can lead to vision loss.

  3. Antibacterial and Antifungal: CBG has demonstrated antibacterial properties, particularly against antibiotic-resistant bacteria like MRSA. Its ability to fight infections may contribute to its potential use in treating skin conditions and infections.

  4. Neuroprotective Properties: Some research suggests that CBG could help protect neurons and promote brain health, possibly making it useful in treating neurodegenerative diseases like Alzheimer's and Parkinson's.

While more research is needed to validate these potential benefits, the emerging evidence suggests that CBG could play a significant role in a wide range of therapeutic applications.

What Do CBD and CBG Have in Common?

Despite their differences, CBD and CBG share several key features:

  1. Non-Psychoactive: Both CBD and CBG are non-intoxicating, meaning they don’t produce the “high” commonly associated with cannabis use. This makes them appealing to those who want to experience the potential therapeutic benefits of cannabis without the psychoactive effects of THC.

  2. Interaction with the Endocannabinoid System (ECS): Both cannabinoids interact with the body’s ECS, which helps regulate essential bodily functions like mood, sleep, pain, and immune response. While CBD works by inhibiting the breakdown of the body’s natural endocannabinoids, CBG is believed to interact directly with the CB1 and CB2 receptors in the ECS, leading to a different range of effects.

  3. Anti-Inflammatory Effects: Both CBD and CBG are known for their potent anti-inflammatory properties. This makes them useful in treating various inflammatory conditions, including chronic pain, autoimmune diseases, and neurological disorders.

CBG and CBD: What is the difference?

Key Differences Between CBD and CBG

Though CBD and CBG share common properties, they differ in several important ways:

  1. Chemical Structure and ECS Interaction: While both cannabinoids interact with the ECS, they do so in different ways. CBD primarily inhibits the breakdown of endocannabinoids, enhancing the effects of the ECS. In contrast, CBG directly interacts with CB1 and CB2 receptors, which may lead to a broader range of effects.

  2. Abundance in Cannabis Plants: CBD is more prevalent in cannabis plants and is typically found in higher concentrations. On the other hand, CBG is present in much lower amounts, making it harder and more expensive to extract.

  3. Research and Knowledge: CBD is one of the most studied cannabinoids, with extensive research supporting its potential health benefits. CBG, however, is still in the early stages of research, and more studies are needed to understand its full therapeutic potential.

Legal Status of CBD and CBG

In the United States, both CBD and CBG are legal when derived from hemp plants containing 0.3% or less THC, as per the 2018 Farm Bill. However, the legality of these cannabinoids can vary depending on their source. If derived from marijuana plants containing more than 0.3% THC, the legal status can differ by state.

It's important to note that while CBD and CBG are legal at the federal level when derived from hemp, the Food and Drug Administration (FDA) does not regulate most CBD and CBG products. This lack of regulation can lead to inconsistent product quality and effectiveness. Consumers should be cautious and seek third-party lab-tested products to ensure safety and quality.

Pros and Cons of CBD

Pros:

  • Well-Researched: CBD has been extensively studied, with significant evidence supporting its therapeutic uses, particularly in pain management, anxiety reduction, and seizure treatment.

  • Non-Psychoactive: CBD is ideal for those who want to experience the benefits of cannabis without the intoxicating effects of THC.

  • Availability: CBD products are widely available in various forms, making it easy to find one that suits individual preferences.

Cons:

  • Regulation Issues: The lack of FDA regulation raises concerns about product consistency, quality, and safety.

  • Side Effects: While generally safe, CBD can cause side effects in some people, such as dry mouth, fatigue, and potential drug interactions.

  • Cost: High-quality CBD products can be expensive, limiting accessibility for some users.



Pros and Cons of CBG

Pros:

  • Potential Health Benefits: CBG shows promise for a variety of therapeutic applications, including anti-inflammatory, antibacterial, and neuroprotective effects.

  • Non-Psychoactive: Like CBD, CBG doesn't produce a high, making it a safe alternative for those seeking therapeutic benefits.

  • Enhanced Entourage Effect: Some research suggests that CBG may enhance the therapeutic effects of other cannabinoids when used together, potentially increasing their overall efficacy.

Cons:

  • Limited Research: Although early studies are promising, more research is needed to fully understand CBG’s therapeutic potential.

  • Availability and Cost: CBG is found in smaller amounts in cannabis plants, making it more expensive and harder to extract.

  • Regulation Issues: As with CBD, CBG products are largely unregulated by the FDA, leading to concerns about product quality and safety.

Conclusion: CBD vs. CBG – Which is Right for You?

Both CBD and CBG have potential health benefits and offer non-intoxicating alternatives to THC. While CBD is more well-researched and widely available, CBG is an emerging cannabinoid that shows promise for a variety of therapeutic uses. However, both cannabinoids face challenges due to the lack of FDA regulation, and consumers should carefully research products before purchasing.

Ultimately, whether you choose CBD or CBG will depend on your specific health goals and the availability of products. Always consult with a healthcare provider before incorporating any cannabinoid into your wellness routine to ensure it aligns with your needs.

If you're interested in accessing CBD products legally, CannabisMD TeleMed is the best place to obtain your medical marijuana card. With professional consultations and personalized care, CannabisMD TeleMed makes it easy to connect with healthcare providers who can help guide your wellness journey. Whether you’re seeking relief from chronic pain, anxiety, or other conditions, CannabisMD TeleMed offers the support you need to make informed decisions about using cannabis for your health.

For more information on the benefits of CBD, CBG, and other cannabis-derived compounds, or to schedule your online consultation and obtain your medical marijuana card, visit CannabisMD TeleMed today.



FAQs

Which is better CBD or CBG?
Neither CBD nor CBG is definitively better, as each offers unique benefits. CBD is widely researched and effective for conditions like pain, anxiety, and epilepsy, while CBG is still emerging but shows promise for treating conditions like glaucoma and inflammatory bowel disease. The choice between them depends on individual health needs and the desired therapeutic effects.

What does CBG do for you?
CBG has shown potential in reducing inflammation, improving eye health, and offering neuroprotective benefits. It's being researched for its possible use in treating conditions like glaucoma, inflammatory bowel disease, and neurodegenerative diseases. However, more studies are needed to confirm its full range of therapeutic effects.

What is the difference between CBN, CBD, and CBG?
CBN (Cannabinol), CBD (Cannabidiol), and CBG (Cannabigerol) are all cannabinoids with distinct effects. CBN is known for its sedative properties and is often used for sleep support, CBD is widely used for pain, anxiety, and inflammation, and CBG shows promise for treating conditions like glaucoma and inflammatory bowel disease. Each interacts with the endocannabinoid system differently to provide various health benefits.

Does CBD CBG make you sleepy?
While CBD may have mild sedative effects, making it helpful for sleep-related issues, CBG is generally not known to cause sleepiness. Instead, CBG may offer neuroprotective and anti-inflammatory benefits, though individual responses vary. It’s best to monitor how both affect you personally.

What are the downsides of CBG?
The primary downside of CBG is that it is less researched compared to CBD, meaning its full range of effects and safety profile are not yet fully understood. Additionally, CBG is found in lower concentrations in cannabis plants, which can make it more expensive and harder to extract. Like other cannabinoids, CBG products can be unregulated, leading to concerns about quality and consistency.

Headshot of Steven Fiore, MD

This article has been reviewed
by Steven Fiore, MD.

Ukeme Akpan

I have been researching and writing topics related to medical cannabis for many years. My goal is to create educational content.

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